Diindolylmethane (DIM) Information Resource Center

Diindolylmethane (DIM)
Information Resource Center

An Initiative of Faculty Members and Research Fellows at the
University of California at Berkeley

An Initiative of Faculty Members and
Research Fellows at the
University of California at Berkeley

Diindolylmethane (DIM) Information Resource Center

Diindolylmethane (DIM) Information Resource Center References Section

Providing References for Biomedical Investigators Conducting Research on Diindolylmethane (DIM) and DIM Supplement Formulations

Diindolylmethane (DIM) Scientific Reference 21 From 2009:

Chem Pharm Bull (Tokyo). 2009 May;57(5):536-40.

Enhancement of chemically-induced HL-60 cell differentiation by 3,3′-diindolylmethane derivatives.

Noguchi-Yachide T, Tetsuhashi M, Aoyama H, Hashimoto Y.

Institute of Molecular & Cellular Biosciences, The University of Tokyo, Tokyo, Japan.

3,3′-Diindolylmethane (DIM, 1) and its derivatives have been prepared, and their enhancing effects on chemically-induced HL-60 cell differentiation were analyzed. Among the prepared compounds, IndDIM (12) showed the most potent enhancing effect on HL-60 cell differentiation induced by chemicals, including retinoids, 1,25-dihydroxyvitamin D(3), 12-O-tetradecanoyl phorbol-13-acetate and dimethyl sulfoxide.