Diindolylmethane (DIM) Information Resource Center

An Initiative of Faculty Members and Research Fellows at the

University of California at Berkeley

 

Diindolylmethane (DIM) Information Resource Center

Diindolylmethane (DIM) Information Resource Center

Diindolylmethane (DIM) Information Resource Center

 

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Mission

 

The goal of the Diindolylmethane Information Resource Center is to provide an accurate scientific summary of Diindolylmethane (DIM) for consumers and biomedical investigators. It is a collaborative initiative of faculty members and research fellows at the University of California at Berkeley.

 

About DIM

 

Diindolylmethane (DIM) is a naturally occurring compound found in Brassica vegetables such as broccoli, cabbage, Brussels sprouts, cauliflower and kale. DIM is currently under investigation as a naturally occurring therapeutic for cancer, infectious diseases and immune deficiency conditions due to its potent anti-cancer and immune modulating properties. The compound is formed during the autolytic breakdown of glucobrassicin present in Brassica vegetables. The autolytic breakdown of glucobrassicin requires the catalytic reaction of the enzyme myrosinase which is endogenous to these plants and released upon the rupturing of the cell wall of the plant.

 

Diindolylmethane Molecular Weight, Crystalline Characteristics & Molecular Structure

 

Diindolylmethane has a molecular weight of 246 and is pale yellow in crystalline form. The purified compound does not have any taste.

 

 3,3-Diindolylmethane

 Diindolylmethane (DIM)

Solubility and Bioavailability

Diindolylmethane is a lipophilic oil-soluble compound. Similar to other oil-soluble phytochemicals, such as lycopene and lutein, the presence of vegetable oil and other lipophilic compounds, such as phosphatidylcholine, that aid in the formation of absorption micelles within the gastrointestinal tract, greatly increase the bioavailability of DIM upon oral administration. Most of the preclinical animal studies and some of the human clinical trials conducted with DIM have consisted of DIM co-administered with vegetable oils. Some of the formulations have additionally contained phosphatidylcholine and other lipophilic excipients for enhanced absorption. When formulated correctly, Diindolylmethane is a highly bioavailable compound.

News Brief from Berkeley

 

A Bioavailable Diindolylmethane Immune Support Formula has been launched with technology exclusively licensed from UC Berkeley as a fund-raiser for nature-based cancer therapeutics research. For more information about this formula, please visit: www.ActivaMune.com.

Diindolylmethane (DIM) Information Resource Center

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